Evaluation of the course and treatment of Alcohol Withdrawal Syndrome with the Clinical Institute Withdrawal Assessment for Alcohol – Revised: A systematic review-based meta-analysis

Although the Clinical Institute Withdrawal Assessment for Alcohol – Revised (CIWA-Ar) is a gold standard tool clinical evaluation of alcohol withdrawal syndrome (AWS), systematic analysis using total scores CIWA-Ar as means an objective follow-up course and treatment AWS missing. The aims present study were to systematically evaluate scientific data CIWA-Ar, reveal whether aggregated follow compare benzodiazepine (BZD) non-benzodiazepine (nBZD) therapies in AWS. 1054 findings identified with keyword “ciwa” from four databases (PubMed, ScienceDirect, Web Science, Cochrane Registry). Articles patients treated incorporated two measurement intervals (cumulative mean day 1−3 4−9) compared. Subgroup based on pharmacotherapy regimen was conducted effectiveness BZD nBZD treatments. random effects 423 showed decreased between (BZD: d = –1.361; CI: –1.829 < δ –0.893; nBZD: –0.858; –1.073 –0.643). Sampling variances calculated (v1 0.215) (v2 0.106) groups, which indicated no significant group difference (z −1.532). Our support that follows Furthermore, therapy has similar compared scores.